Analysis of ALK Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1129-LGZ)

Introduction

Official Full Name: ALK receptor tyrosine kinase<br />Also known as: ALK1; CD246; NBLST3<br />This gene encodes a receptor tyrosine kinase that belongs to the insulin receptor superfamily. The protein consists of an extracellular domain, a hydrophobic stretch corresponding to a single-pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and affects specific neurons in the nervous system. The gene has been found to be rearranged, mutated or amplified in a range of tumors, including anaplastic large cell lymphoma, neuroblastoma and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumorurigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosomal some 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19) , and ALK/MSN (chromosome X).