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Apolipoprotein E (APOE), a secreted protein synthesized by liver cells and brain tissues, binds to a variety of receptors on the surface of different cells and plays a key role in lipid metabolism, immune regulation and neurology. ApoE is a polymorphic protein involved in the transformation and metabolism of lipoprotein, and its genes can regulate many biological functions, which is related to the pathogenesis of many eye diseases. The research on APOE and its gene polymorphism is one of the hot spots in medical research, and the exploration of the internal relationship between the two has important clinical application value for the prevention, diagnosis and treatment of eye diseases.