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B7-H6 is a ligand for the NK cell-activating receptor NKp30, which triggers cytotoxicity and cytokine secretion against tumor natural killer (NK) cells. Both forms of B7-H6 (cell surface B7-H6 and soluble B7-H6 (sB7-H6)) are detected in primary tumors and the tumor microenvironment, but are rarely found in normal tissues.