Analysis of Cystatin C (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0127-LGZ)

Introduction

Cysteine proteinase inhibitor (CP) was named cystatin C. Known as gamma-trace protein and gamma-globulin, widely exist in all kinds of tissue nucleated cells and body fluids, is a low molecular weight, basic non-glycated protein, molecular weight of 13.3KD, composed of 122 amino acid residues, can be produced by the body all nucleated cells, the production rate is constant. Circulating cystatin c is cleared only by glomerular filtration, an endogenous marker reflecting changes in glomerular filtration rate. It is reabsorbed in the proximal curving tubule, but is completely metabolized after reabsorption and does not return to the blood. Therefore, its blood concentration is determined by glomerular filtration rate, independent of any external factors such as sex, age, and diet. It is an ideal endogenous marker to reflect the change of glomerular filtration rate.