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Elastase 2 is a chymotrypsin family serine protease that plays an important role in pathogen clearance. It is expressed by promyelocytes and stored in intracellular azurophilic granules of polymorphonuclear leukocytes. ELA2 can degrade a variety of extracellular matrix proteins, including elastin and fibronectin. Multiple mutations in the ELA2 gene cause severe congenital and cyclic neutropenia.