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Epithelial cell adhesion molecule (EpCAM), also known as CD326, is a single-channel, type I plasma membrane glycoprotein, homotype Ca2+-independent cell adhesion molecule. In addition to its role in cell-cell adhesion, in vitro and in vivo studies have shown that EpCAM plays an important role in cell signaling, proliferation, differentiation, organ formation, and maintenance. EpCAM is expressed in a variety of epithelial tissues and is also a cell surface marker of a variety of stem and progenitor cells.