Analysis of Granulin/GRN by ELISA (CAT#: STEM-MB-1583-LGZ)

Introduction

Granulin (GRN) is encoded in humans by the GRN gene. Its precursor protein-granulin precursor, also known as teratoma cell-derived growth factor. After the signal peptide is cleaved, mature GRN can be produced, and further cleavage can produce many active polypeptides with a molecular weight of 6 kDa. Both peptide and intact GRN regulate cell growth. However, different members of the GRN protein family may exert inhibitory and/or promoting effects on cell growth. Members of the GRN family play important roles in normal development, wound healing, and tumorigenesis. GRN may have cytokine-like activity and play a role in inflammation, wound repair and tissue remodeling. Human liver flukes secrete GRN-like growth hormones that contribute to the development of cholangiocarcinoma. Mutations in the GRN gene can be inherited through autosomal dominant inheritance with high penetrance, producing up to 25% of frontotemporal lobar degeneration.