Analysis of α-GST (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0636-LGZ)

Introduction

Glutathione S-transferase A1 is an enzyme encoded by the GSTA1 gene. The cell membrane and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function by conjugating glutathione to detoxify electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress. It is well known that the genes encoding these enzymes are highly polymorphic. These genetic variations can alter a person's susceptibility to carcinogens and toxins and affect the toxicity and efficacy of some drugs. Currently, eight distinct classes of soluble cytoplasmic mammalian glutathione S-transferases have been identified: α, kappa, mu, omega, pi, sigma, theta, and zeta.