Analysis of HTRA4 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1877-LGZ)

Introduction

Official Full Name: HtrA serine peptidase 4
This gene encodes a member of the HtrA protease family. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies by other related family members, this enzyme may be a secreted oligomeric chaperone protease that degrades misfolded secreted proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis and aging.