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Interleukin (IL)-22 belongs to the IL-10 family of cytokines. IL-22 exerts its biological effects through class 2 members of the cytokine receptor family. CD4+ T helper (Th) cells that mainly produce IL-22 are called Th22 cells. IL-22/Th22 cells are functionally related to IL-17/Th17 cells, but there are significant differences. Both IL-22 and IL-17 are cytokines that recruit neutrophils during microbial invasion. In chronic inflammation, IL-22 mediates protective and regenerative processes, whereas IL-17 cytokine tends to induce inflammation.