Analysis of IL-36γ (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0345-LGZ)

Introduction

IL-36 belongs to the IL-1 cytokine family. IL-36 can only become active functional form after N-terminal shear, which plays an important role in inflammation and tumor immunity. Il-36α, IL-36β, and IL-36γ are cleaved into active forms, bind to IL-36 receptors, transmit signals via MyD88-MAPK/IKK-AP1/NF-κB, and eventually release cytokines (IL-36, etc.), chemokines, and promote inflammation.

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Principle Applications Procedure Materials Notes Related Products

Principle

MSD electrochemiluminescence technology is mainly based on ultra-sensitive multi-factor electrochemiluminescence analyzer MES0 Sector600 or Quickplex SQ120. Through dot matrix technology, the detection of 10 indicators per well can be realized in the 96-hole graphite electrode plate. It can also be customized to realize the screening detection of 100 index wells in a 24-well plate.

Applications

Cytokines & Chemokines, Immunology/Inflammation

Procedure

1. Coat the capture antibody on the well plate.
2. Add samples/calibrators.
3. Add detection antibody.
4. Read the plate and analyze the data.

Materials

• Sample Type: Plasma, Serum

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