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LDLR (low-density lipoprotein receptor, also known as FH; FHC; FHCL1; LDLCQ2) is located at 19p13.2 and is conserved in chimpanzee, rhesus monkey, dog, cow, mouse, rat, zebrafish and frog. The gene produces a 95376 Da protein consisting of 860 amino acids. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands.