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Official Full Name: mitochondrial amidoxime reducing component 2
Also known as: MARC2; MOSC2
The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein takes molybdenum as cofactor, cytochrome b5 type B and NADH cytochrome b5 reductase as cofactors. One of the substrates used is an N-hydroxynucleotide-based analogue, which can be toxic to cells. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants of this gene have been found encoding different isoforms.