Analysis of NRAS Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-1151-LGZ)

Introduction

Official Full Name: NRAS proto-oncogene, GTPase
Also known as: NS6; CMNS; KRAS; NCMS; ALPS4; N-ras; NRAS1
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.