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Official Full Name: Parkinsonism associated deglycase
Also known as: DJ1; DJ-1; GATD2; HEL-S-67p
The product of this gene belongs to the peptidase C56 protein family. It is a positive regulator of androgen receptor-dependent transcription. It also acts as a redox-sensitive chaperone, as a sensor of oxidative stress, and it apparently protects neurons from oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease7. Two transcript variants of this gene have been identified encoding the same protein.
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