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Official Full Name: proline and arginine rich end leucine rich repeat protein
Also known as: MST161; SLRR2A; MSTP161
The protein encoded by this gene is a leucine-rich repeat protein present in the extracellular matrix of connective tissue. The protein functions as a molecule that anchors the basement membrane to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membrane and type II collagen to cartilage. It also binds basement membrane heparan sulfate proteoglycan. This protein is thought to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which has been reported to lack collagen binding in basement membrane and cartilage. Alternative splicing transcript variants encoding the same protein have been observed.