Analysis of PTPN7 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0607-LGZ)

Introduction

Official Full Name: protein tyrosine phosphatase non-receptor type 7<br />Also known as: LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP<br />The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTP is known to be a signaling molecule that regulates a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene of cells stimulated by lymphokines. The non-catalytic N-terminus of this PTP can interact with MAP kinase and inhibit the activity of MAP kinase. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to act by dephosphorylating molecules associated with the MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene.