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Official Full Name: protein tyrosine phosphatase non-receptor type 7
Also known as: LPTP; HEPTP; PTPNI; BPTP-4; LC-PTP
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTP is known to be a signaling molecule that regulates a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene of cells stimulated by lymphokines. The non-catalytic N-terminus of this PTP can interact with MAP kinase and inhibit the activity of MAP kinase. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which is thought to act by dephosphorylating molecules associated with the MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene.