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Official Full Name: RAD21 cohesin complex component
Also known as: MGS; HR21; MCD1; NXP1; SCC1; CDLS4; hHR21; HRAD21
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, which is involved in the repair of DNA double-strand breaks and the cohesion of chromosomes during mitosis. This protein is a nuclear phosphorylated protein that is hyperphosphorylated during the M phase of the cell cycle. The highly regulated association of this protein with mitotic chromatin, particularly at the centromere region, suggests its role in sister chromatid cohesion in mitotic cells.