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Resistin, also known as FIZZ3 or ADSF, belongs to the family of resistin-like molecules (RELMs), and is related to obesity and insulin resistance. The amount of newly synthesized MMPs is mainly controlled by the level of replication. The activity of MMPs is mainly regulated by the activation of zymogens and their inhibitory proteins (TIMPs). RESISTIN is a true collagenase that can degrade type Ⅰ, Ⅱ, and Ⅲ collagenase.