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Official Full Name: S100 calcium binding protein A12<br />Also known as: p6; CAGC; CGRP; MRP6; CAAF1; MRP-6; ENRAGE<br />The protein encoded by this gene is a member of the S100 protein family, which contains two EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a variety of cells and are involved in the regulation of many cellular processes, such as cell cycle progression and differentiation. The S100 gene includes at least 13 members, which are located on chromosome 1q21. This protein is thought to be involved in specific calcium-dependent signal transduction pathways, and its regulation of cytoskeletal components may regulate various neutrophil activities. The proteins include antimicrobial peptides with antibacterial activity.