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Official Full Name: S-antigen visual arrestin
Also known as: RP47; RP96; S-AG
Members of the arrestin family are thought to be involved in agonist-mediated desensitization of G protein-coupled receptors and cause specific inhibition of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals . S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein involved in desensitization of light-activated transduction cascades. It is expressed in the retina and pineal gland and inhibits the conjugation of rhodopsin to transducin in vitro. Furthermore, s-arrestin is highly antigenic and capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene are associated with Oguchi disease, a rare form of autosomal recessive night blindness.