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CD163 is a protein encoded in humans by the CD163 gene. It belongs to the cysteine-rich B-type scavinger receptor family, which contains an extracellular domain of 1048 amino acid residues, a single transmembrane segment, and a cytoplasmic tail region with several splicing variants. It is a scavenger receptor of the hemoglobin-bound globin complex and can label monocyte/macrophage lineages. The soluble form of this receptor is found in plasma and is usually represented as sCD163. sCD163 is produced by extracellular shedding of membrane bound receptors and is upregulated in a wide range of inflammatory diseases including cirrhosis, type 2 diabetes, macrophage activation syndrome, Gorscher's disease, sepsis, HIV infection, rheumatoid arthritis, and Hodgkin's lymphoma.