Analysis of U-PAR by ELISA (CAT#: STEM-MB-1253-LGZ)

Introduction

Urokinase-type plasminogen activator receptor (U-PAR) is a multi-domain glycoprotein cell surface receptor anchored on the cell membrane by GPI, which binds urokinase-type plasminogen activator (uPA) with high affinity , thereby promoting the activation of plasminogen cells. U-PAR binds urokinase, limiting the activation of plasminogen near the cell membrane periphery. In addition to the main ligand urokinase, U-PAR also interacts with other proteins. U-PAR and uPA are the main members of the plasmin activation system and are multifunctional molecules that coordinate various signal transduction pathways. In healthy organisms, involved in tissue reorganization such as mammary gland regression and wound healing. In addition to coagulation-fibrinolysis, U-PAR participates in processes such as cell migration, cell cycle regulation, and cell adhesion, thereby participating in various disease processes such as Tumor invasion and inflammation.