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Also known as: SOC; SOCI; COA-1; UBXD5; PP2243
This gene encodes a protein with a differentiated C-terminal UBX domain. The homologous protein in rat interacts with members of the Rnd subfamily of Rho GTPases at the cell periphery through its C-terminal region. It also interacts with several heterotrimeric G proteins via the G-α subunit, promoting Rho GTPase activation. It is thought to play a bidirectional role in promoting and inhibiting Rho activity through upstream signaling pathways. The 3' coding sequence of the gene contains a polymorphic region of 24nt tandem repeat sequence. Some transcripts contain 1.5 to 5 repeat units. Multiple transcript variants encoding different isoforms have been found for this gene.