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CD16a is a transmembrane protein expressed by lymphocytes and some monocytes.
IgG binds to cell surface receptors on many types of cells to bring about an assortment of effects: the enabling of phagocytosis (monocytes, macrophages, neutrophils) or antibody-dependent cellular cytotoxicity (monocytes, macrophages and lymphocytes) or to effect feedback control on antibody synthesis (B and T). Protein A or G are the most common affinity ligands used for purification of IgG.