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This service provides a method-pressure assisted partial filling affinity capillary electrophoresis-to study noncovalent molecular interactions of the hexamer of human insulin (HI) with biologically relevant ligands, basic phenolic neurotransmitters serotonin and dopamine, basic amino acid arginine, and very weakly acidic phenol, in alkaline aqueous media. Human insulin (HI) is one of the key protein hormones controlling metabolism, growth, and ageing. Its malfunction causes diabetes, some types of cancer, and Alzheimer's disease. HI is a 51-amino acid protein consisting of two disulfide-linked chains (A1-A21, B1-B30); it is produced from a single chain proinsulin. HI is stored in pancreatic β-cells in secretory granules, which contain high concentration of both insulin and zinc ions.