Human Recombinant FGFacidic, ACF, STEMCELL Technologies (CAT#: STEM-CT-0867-ZJF)

Fibroblast growth factor acidic (FGF-acidic), also known as FGF-1, is a potent activator of DNA synthesis, cell proliferation, and chemotaxis and is known to play numerous roles in development, regeneration, and angiogenesis (Galzie et al.; Jaye et al.; Presta et al.). FGF-acidic is produced by multiple cell types and is capable of activating all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It is found in large quantities in the brain, but is also expressed in hepatocytes, vascular smooth muscle cells, neurons of the central nervous system, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelial cells, and pituitary basophils and acidophils. FGF-acidic is secreted as a disulfide-linked homodimer and is stored in complex with heparan sulfate, a requirement for its interaction with FGF receptors (Guerrini et al.; Mohammadi et al.). Internalized FGF-acidic signals via protein kinase C and promotes cell survival by inhibiting p53 and proapoptotic signaling (Bouleau et al.). This product is animal component-free.

Subtype: Cytokines, Growth Factors
Alternatives Names: Acidic fibroblast growth factor, aFGF, ECGF, Endothelial cell growth factor, FGF-1, FGF-alpha, Fibroblast growth factor 1, GLIO703, HBGF-1, Heparin-binding growth factor 1
Cell Type: Endoderm, PSC-Derived, Endothelial Cells, Epithelial Cells, Fibroblasts, Granulocytes and Subsets, Hepatic Cells, Keratinocytes, Mesoderm, PSC-Derived, Neurons, Smooth Muscle
Species: Human
Area of Interest: Immunology, Neuroscience, Stem Cell Biology
Formulation Category: Animal Component-Free
Molecular Weight: 16.0 kDa
Purity: ≥ 95%

Reliable Consistency: Guarantees uniformity and repeatability in various applications with endotoxin levels below 0.2 EU/μg.
Free of Animal Components: Completely devoid of any animal or human-derived elements.
Broad Selection: Offers a wide range of human, mouse, and rat cytokines available in multiple sizes.

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