Recombinant Human HER2 Protein, Seafrom (CAT#: STEM-CT-0120-ZJF)

The Recombinant Human HER2 Protein manufactured by Seafrom is suitable for cancer therapy and research.
Human Epidermal Growth Factor Receptor 2 (HER2), also known as ERBB2, HER-2, HER-2/neu, neu, NGL, TKR1, and c-ERBB2, is a protein associated with high invasiveness in breast cancer. It is a member of the ErbB protein family, commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane-bound receptor tyrosine kinase that typically participates in signaling pathways leading to cell growth and differentiation. It is considered an orphan receptor, as no ligand from the EGF family can activate it. Approximately 30% of breast cancers show HER2 gene amplification or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and poor prognosis, and it also plays a role in development, cancer, communication at neuromuscular junctions, and the regulation of cell growth and differentiation.
Storage Information:
Lyophilized samples can be stored at 2-8°C for 24 months. If you need to aliquot the samples, you can dissolve them in injection water, saline, culture medium, or PBS. After dissolution, store them in small aliquots at -20°C for 6 months or at -80°C for 12 months, taking care to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Synonyms: ERBB2, CD340, HER-2/neu, MLN19, NEU, NGL, TKR1
Protein Sequence: The DNA sequence encodes human HER2 (UniProtKB - P04626), expressed with a His tag at the C-terminus.
Molecular Weight: Recombinant human HER2 protein contains 630 amino acids, with a predicted theoretical molecular weight of 71 kD.
Purity: >95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg (gel method)
Biological Activity: At a concentration of 100 ng/mL (100 μL/well), immobilized human HER2 (His tag) can bind to anti-human HER2 antibody in a linear range of 0.1-5 ng/mL.
Purification Method: Chromatographic purification

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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