In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem by Patch clamp (CAT#: STEM-PET-0072-WXH)

Introduction

The locus coeruleus (LC) is located in the posterior area of the rostral pons in the lateral floor of the fourth ventricle. It is composed of mostly medium-size neurons. Melanin granules inside the neurons of the LC contribute to its blue colour.
Locus coeruleus (LC) neurones extend noradrenergic projections throughout the neuroaxis and are involved in homeostatic functions such as pain modulation, arousal and cardio-respiratory control.