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In Vivo Pharmacodynamic Evaluation of Nephrectomy Induced Chronic Kidney Disease Model (CAT#: STEM-AE-0670-LGZ)

Introduction

Metabolic diseases are diseases caused by the accumulation or deficiency of certain metabolic substances such as sugars, fats, proteins (amino acids), purines, pyrimidines, and copper when biochemical processes in the body are disrupted. Symptoms vary in severity and diagnosis depends on clinical manifestations and blood, urine and other biochemical tests. There is no effective cure, the main is to eliminate the cause and symptomatic treatment. The prognosis depends on the etiology, severity of symptoms and treatment effect.




Principle

5/6 nephrectomy produced high perfusion and filtration pressure to the remaining nephrons of mice. The residual nephrons were further destroyed, thus leading to chronic kidney disease characterized by sclerosis and hypertrophy of glomeruli.

Applications

Metabolic Disease

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder
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