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Ion selective electrode (ISE) is an analytical technique used to determine the activity of ions in aqueous solution by measuring the electrical potential. ISE has many advantages compared to other techniques, including:
It is relatively inexpensive and easy to operate.
It has wide concentration measurement range.
As it measure the activity, instead of concentration, it is particularly useful in biological/medical application.
It is a real-time measurement, which means it can monitor the change of activity of ion with time.
It can determine both positively and negatively charged ions.