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The extremely hydrophobic C60 fullerene can be made soluble in water by connecting it with functional chargeable groups such as carboxylic acids or amines. Hydrophilic behavior can also be introduced by an elegant and less obvious approach, one in which polarizable phenyl groups are added to C60 to stabilize its anion. Because these compounds are composed solely of carbon and hydrogen atoms, they represent a rare example of a hydrophobic hydrocarbon ball linked to a hydrophilic ion, causing the pentasubstituted fullerene to achieve a surfactant functionality. The low solubility of fullerenes in aqueous solution limits their applications in biology. By appropriate substitution, the fullerenes can be transformed into stabilized anions that are water soluble and can form large aggregated structures.