Study of Viscoelasticity of Amyloid Plaques in Transgenic Mouse Brain by Brillouin Scattering (CAT#: STEM-ST-0135-YJL)

Introduction

Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the leading cause of dementia worldwide, and is characterized by the accumulation of amyloid plaques in the brain parenchyma. The plaques consist of abnormal deposits mainly composed of an aggregation-prone protein fragment, β-amyloid 1-40/1-42, into the extracellular matrix. Amyloid deposits can build up in the heart, brain, kidneys, spleen and other parts of the body. A person may have amyloidosis in one organ or several.

Add to Cart Please Inquire

Principle Applications Procedure Materials Notes Related Products

Principle

From a quantum point of view, Brillouin scattering is an interaction of light photons with acoustic or vibrational quanta (phonons), with magnetic spin waves (magnons), or with other low frequency quasiparticles interacting with light. The interaction consists of an inelastic scattering process in which a phonon or magnon is either created (Stokes process) or annihilated (anti-Stokes process). The energy of the scattered light is slightly changed, that is decreased for a Stokes process and increased for an anti-Stokes process. This shift, known as the Brillouin shift, is equal to the energy of the interacting phonon and magnon and thus Brillouin scattering can be used to measure phonon and magnon energies.

Applications

Brillouin scattering is used to determine acoustic velocities and elastic properties of a number of crystalline solids, glasses, and liquids.

Procedure

1. Sample preparation
2. Measurement by scattering detection instrument
3. Data analysis

Materials

Brillouin scattering measurement system (Brillouin spectrometer)

Other recommended products

Study of Biomechanical Properties of Murine Embryos Using Brillouin Scattering (CAT#: STEM-ST-0126-YJL)
Measurement of Wave Velocity in Cortical Bone by Brillouin Scattering (CAT#: STEM-ST-0136-YJL)
Study of Mechanical Properties of Amorphous PEI, PES, and PVC by Brillouin Scattering (CAT#: STEM-ST-0113-YJL)
Study of Characterization of Thin Metallic Films by Brillouin Scattering (CAT#: STEM-ST-0094-YJL)
Study of Mechanical Characterization of 3D Ovarian Cancer Nodules Using Brillouin Scattering (CAT#: STEM-ST-0130-YJL)
Measurement of Poisson's Ratio of Optical Fibers and its Temperature Dependence Using Forward-Stimulated Brillouin Scattering (CAT#: STEM-ST-0157-YJL)
Study of High-Sensitivity and High-Specificity Biomechanical Imaging by Stimulated Brillouin Scattering (CAT#: STEM-ST-0117-YJL)
Study of Aqueous Suspensions of Poly-N-Isopropylacrylamide Microgel Particles by Brillouin Scattering (CAT#: STEM-ST-0139-YJL)