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The sugar water preference experiment, also known as the double-bottle drinking choice experiment, is an animal behavioral experimental method for studying drug addiction (alcohol oral administration) and depressive behavior. Rodents naturally have a sweet taste preference, and when the mice exhibited depression-like behavior, their preference for sugar water was also reduced. Anhedonia is an important feature of mental illness and behavioral disorders. This is also what most depression patients describe as "the world is gray, and I can't feel what is happiness". Based on this principle, the sugar water preference test is used to evaluate the depression-like behavior of animals and the effect of antidepressant drugs.