The Holeboard Test (CAT#: STEM-AE-0008-WXH)

Introduction

In this experiment, two factors of curiosity and fear are used to control the behavior of animals in a new environment, and escapes are used to reflect the effect of these two factors. The animal's repeated head-dipping reflects its sense of novelty and desire to escape. It is generally believed that the drug increases the number and time of drilling at a dose that does not affect the animal's motor activity, which is an anxiolytic effect, and decreases the number and time of drilling is an anxiolytic effect.
The experimental device is an elevated orifice through which the animal's head can be drilled.

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Principle Applications Procedure Materials Notes Related Products

Applications

Drug efficacy research

Procedure

Male adult rats or mice were used for experiments. The animal is placed in the center of the well plate, facing away from the observer. When the eyes of the animal disappear into the hole, it is a drill (a head-dip), and the number of drills and the duration of the drill are recorded for 5-10 minutes.

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