Total virus particle determination by Nanoparticle tracking analysis (NTA) (CAT#: STEM-MB-0709-WXH)

Introduction

Vaccines play an important role in the prevention and treatment of disease. Although vaccines have been used for decades, there has only recently been a concerted effort to optimize their production and improve vaccine safety and efficacy. Apart from vaccines, where virus particles work as a preventive tool, they also have the potential to work as therapeutics: viral vectors for gene therapy and bacteriophages for the treatment of bacterial infections.

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Principle Applications Procedure Materials

Principle

Nanoparticle tracking analysis (NTA) is a method for visualizing and analyzing particles in liquids that relates the rate of Brownian motion to particle size. The rate of movement is related only to the viscosity and temperature of the liquid; it is not influenced by particle density or refractive index. NTA allows the determination of a size distribution profile of small particles with a diameter of approximately 10-1000 nanometers (nm) in liquid suspension.

Applications

NTA has been used by commercial, academic, and government laboratories working with nanoparticle toxicology, drug delivery, exosomes, microvesicles, bacterial membrane vesicles, and other small biological particles, virology and vaccine production, ecotoxicology, protein aggregation, orthopedic implants, inks and pigments, and nanobubbles.

Procedure

1. Sample preparation
2. Nanoparticle Tracking Analysis
3. NTA Data Processing, Display, and Interpretation

Materials

• Nanoparticle Tracking Analysis (NTA) instrument
• NanoSight instrument
• Nanoparticle Analyzer

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