Analysis of 6CKine/CCL21 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0004-LGZ)

Introduction

CCL21, also known as exodus-2, secondary lymphoid tissue chemokine (SLC), is a small cytokine belonging to the CC chemokine family, located on chromosome 9 in the human genome. CCL21 can be constitutively expressed at the origin of lymphatic vessels and in lymphoid organs, is present on several types of stromal cells and high endothelial venules (HEVs), can bind glycosaminoglycans (GAGs) and fix them on the surface of endothelial cells. As a chemokine, CCL21 can inhibit hematopoiesis and stimulate chemotaxis, and has in vitro chemotactic effects on thymocytes and activated T cells, but not on B cells, macrophages, or neutrophils. At the same time, CCL21 is also a potent stimulator of T cell migration and adhesion, which can bind to the glycoprotein PSGL-1 on T cells to promote the migration of T cells to secondary lymphoid organs. CCL21 can act through the chemokine receptors CCR7 and CXCR3. Among these, CCR7 is a GPCR that is commonly expressed by T cell subsets central memory cells, thymic T cells, B cells, mature DC, and other rare cell subsets. CCL21 can function in the CNS as a microglial activator and is exclusively expressed in endangered or mechanically injured neurons.