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Amphiregulin, AREG is an epidermal growth factor (EGF) -like molecule belonging to the EGF family. It is an autocrine growth factor and a mitogen of astrocytes, Schwann cells, and fibroblasts. AREG gene expression and release is caused by a variety of stimuli, including inflammatory lipids, cytokines, hormones, growth factors, and exogenous drugs. Physiologically, AREG plays an important role in lung morphogenesis and the development and maturation of mammary gland, bone tissue and oocyte. AREG also plays a key role in the restoration of tissue integrity after infection or injury.
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