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Official Full Name: H3.3 histone A<br />Also known as: H3F3; H3-3B; H3.3A; H3F3A; BRYLIB1<br />Histones are fundamental nuclear proteins responsible for the structure of eukaryotic chromosome fibers in the nucleosome. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, and about 146 bp of DNA are packaged in repeating units called nucleosomes. Linker histone H1 interacts with linker DNA between nucleosomes and plays a role in the compaction of chromatin into higher-order structures Unlike most histone genes, this gene contains introns and its mRNA is polyadenylated. The encoded protein is a replication-independent member of the histone H3 family.