Analysis of PIK3C2B Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0572-LGZ)

Introduction

Official Full Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta<br />Also known as: C2-PI3K<br />The protein encoded by this gene belongs to the phosphoinosine 3-kinase (PI3K) family. PI3 kinase plays a role in signaling pathways of cell proliferation, oncogenic transformation, cell survival, cell migration and intracellular protein transport. The protein contains a lipid kinase catalytic domain and a C-terminal C2 domain, a feature of class II PI3 kinases. The C2 domain acts as a calcium-dependent phospholipid-binding motif that mediates protein translocation to membranes and possibly protein-protein interactions. The PI3 kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of the protein binds phospholipids but not Ca2+, suggesting that the enzyme may act in a calcium-independent manner.