Breast Cancer Animal Model (CAT#: STEM-AE-0090-WXH)

Introduction

Breast cancer is a phenomenon in which breast epithelial cells proliferate uncontrollably under the action of various carcinogenic factors. In the early stage of the disease, symptoms such as breast lumps, nipple discharge, and axillary lymph node enlargement are often manifested. In the late stage, cancer cells may metastasize to distant places and cause multiple organ lesions, which directly threaten the lives of patients.

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Principle Applications Procedure Materials Notes Related Products

Applications

Research on the pathogenesis of breast cancer and drug development.

Procedure

• Spontaneous breast cancer animal model (rarely used): Breast cancer occurs naturally without any conscious human manipulation. At present, the mouse spontaneous breast cancer strains include C3H, A, CBA/J, and TA2 strains, and the rat spontaneous breast cancer strains include F334, ACI, Wistar rats, and SD rats.
• Induced breast cancer animal model (rarely used): Use chemical substances, physical and biological factors to apply to experimental animals through oral, smearing, injection and other methods to make them develop breast cancer. Common chemical induction methods use dimethylbenzanthracene (DMBA) and methylnitrosourea (MNU) as inducers to induce breast cancer.
• Transplanted breast cancer animal model (most commonly used, easy to construct)
An animal model in which human or other animal tumor tissues or cells are transplanted into immunodeficient animals to grow into tumors.

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