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Liver cancer is a malignant tumor of the liver, which can be divided into two categories: primary and secondary. In recent years, the incidence of liver cancer has been on the rise worldwide. There are many factors related to the induction of liver cancer, such as viruses, chemical carcinogens, alcohol, etc., but the exact pathogenesis is still unclear. Therefore, the establishment of an animal model that is similar to the biological characteristics of human liver cancer has important practical significance for the study of the pathogenesis of liver cancer and the development of drugs.