Comparative Genomic Hybridisation (CGH) (CAT#: STEM-GT-0016-WXH)

Introduction

CGH is a method of molecular cytogenetic testing that detects chromosomal copy number variants (portions of the genome where sections of genes are doubled or tripled) without the need for cell culturing. It was first developed to identify such changes in tumours.<br />CGH differs from other methods of cytogenetic testing in that it does not rely on a specific target, nor does it require previous knowledge of the region under examination. Instead, CGH can quickly scan a whole genome for chromosomal imbalances and it is useful in cases where the diagnosis is not known. One limitation of CGH is the size of the genetic alteration that it can identify; the resolution of CGH is poor at approximately 5–10 megabases.