DNA micromanipulation by Magnetic tweezers (MT) (CAT#: STEM-MB-1238-WXH)

Introduction

The aim when studying DNA using micromanipulation methods is, besides investigating its topological response, to gradually learn more about the key molecular mechanisms of how DNA maintains its genetic information and how it can be passed further without damage. Indeed, many biological processes can cause severe structural stress to DNA.

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Principle Applications Procedure Materials Notes Related Products

Principle

Magnetic tweezers (MT) are scientific instruments for the manipulation and characterization of biomolecules or polymers. These apparatus exert forces and torques to individual molecules or groups of molecules. It can be used to measure the tensile strength or the force generated by molecules.

Applications

Study of mechanical properties of biological macromolecules like DNA or proteins in single-molecule experiments.
Study of the rheology of soft matter.
Study of force-regulated processes in living cells.

Procedure

1.Sample preparation
2.Force Calibration
3.Measurement
4.Analysis

Materials

Magnetic tweezers

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