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Kruppel-Like Factors (KLFs) are a family of transcription factors with zinc finger structure, which are involved in the regulation of several physiological activities and play a key role in apoptosis, differentiation, proliferation and embryonic development, and are closely related to eukaryotic gene transcriptional regulation.KLF4 is also known as gastrointestinal enriched Kruppel-like factor (GKLF) or epidermal zinc finger factor (EZF), Kruppel-like factor 4 (KLF4), as an important member of the KLFs family, shows high expression in primary hepatocellular carcinoma tissues, and KLF4 plays an important role in the biological function of primary hepatocellular carcinoma.
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