Mechanical Properties of RNA-DNA Hybrid Duplex by Magnetic tweezers (MT) (CAT#: STEM-MB-1253-WXH)

Introduction

RNA can anneal to its DNA template to generate an RNA-DNA hybrid (RDH) duplex and a displaced DNA strand, termed R-loop. RDH duplex occupies up to 5% of the mammalian genome and plays important roles in many biological processes. The functions of RDH duplex are affected by its mechanical properties, including the elasticity and the conformation transitions.