Probing Chromatin Structure by Magnetic tweezers (MT) (CAT#: STEM-MB-1247-WXH)

Introduction

Magnetic tweezers form a unique tool to study the topology and mechanical properties of chromatin fibers. Chromatin is a complex of DNA and proteins that folds the DNA in such a way that meter-long stretches of DNA fit into the micron-sized cell nucleus. Moreover, it regulates accessibility of the genome to the cellular replication, transcription, and repair machinery.

Add to Cart Please Inquire

Principle Applications Procedure Materials Notes Related Products

Principle

Magnetic tweezers (MT) are scientific instruments for the manipulation and characterization of biomolecules or polymers. These apparatus exert forces and torques to individual molecules or groups of molecules. It can be used to measure the tensile strength or the force generated by molecules.

Applications

Study of mechanical properties of biological macromolecules like DNA or proteins in single-molecule experiments.
Study of the rheology of soft matter.
Study of force-regulated processes in living cells.

Procedure

1.Sample preparation
2.Force Calibration
3.Measurement
4.Analysis

Materials

Magnetic tweezers

Other recommended products

Study of Tn5 transposase by Magnetic tweezers (MT) (CAT#: STEM-MB-1271-WXH)
Study of the molecular mechanism of type II topoisomerase poisons by Magnetic tweezers (MT) (CAT#: STEM-MB-1278-WXH)
Study of the dynamic activity of polymerases by Magnetic tweezers (MT) (CAT#: STEM-MB-1233-WXH)
Study of protein-protein interaction (PPI) by Magnetic tweezers (MT) (CAT#: STEM-MB-1263-WXH)
Nucleoid Associated Proteins (NAPs) by Magnetic tweezers (MT) (CAT#: STEM-MB-1270-WXH)
Study of SH3 domain by Magnetic tweezers (MT) (CAT#: STEM-MB-1265-WXH)
Study of DNA packing by a cationic lipid DSTAP by Magnetic tweezers (MT) (CAT#: STEM-MB-1268-WXH)
Analysis of Force Spectroscopy by Magnetic tweezers (MT) (CAT#: STEM-MB-1258-WXH)