RBP4 Signaling Pathway Assay (CAT#: STEM-MB-0377-WXH)

Introduction

Retinol binding protein4 (RBP4) is a newly discovered cytokine that belongs to the retinol binding protein (RBP) family and is mainly secreted by the liver and to a lesser extent by adipose tissue. In both animal and human studies, RBP4 has been found to play a key role in the development and progression of type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease and atherosclerosis by participating in the regulation of glucose uptake and gluconeogenesis, and promoting insulin resistance.

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Principle Applications Procedure Materials Notes Related Products

Principle

The serum RBP4 signaling pathway, through activation of ERK1 / 2 and JAK2 phosphorylation in the MAPK signaling pathway, increases water and sodium retention caused by hyperinsulinemia, overproliferation of vascular smooth muscle cells (VSMCs), and impairs the ability of vascular endothelial cells to synthesize nitric oxide, thus playing an important role in the development of hypertension.

Applications

Study the impact of each clinical virus on the RBP-4 signaling pathway
Research on the regulatory mechanism of RBP-4 signaling pathway in medicine

Procedure

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Notes

Detectable targets: RTK, TRIF, Fas, TLR4, MEKK1, RIP1, TRAF3, Tak1, ISRE, Rac1, IRF9, icam1, RIG-1, TLR3, NAP1, MYD88, GAS, Mda-5, NFκB, MSK1, PI3K, JNK, MSK2, CREB, STAT3, IRS2, TBK1, IRAK4, ISGF3, IRF3, STAT2, PSGL1, Vav, STAT5, TNFR, MAPK, STAT1, SH2, PKR, SLP76, mTOR, TRAM, TYK2, p38MAPK, TRAF5, p50, IRF5, Rel, PI3K, MEK3, IRS1, MEK6, CD3, TLR9

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