ROS1 Signaling Pathway Assay (CAT#: STEM-MB-0308-WXH)

ROS1 can activate signal pathways related to cell differentiation, proliferation, growth and survival, including PI3K-AKT-mTOR pathway. ROS1 can activate downstream signaling pathways by regulating the phosphorylation of downstream pathway proteins, such as PTPN11 (activator of PI3K-mTOR pathway), AKT1, MAPK1, and STAT3 transcription factors.
The common pathogenic mutation of ROS1 gene is gene rearrangement. The resulting ROS1 fusion protein will become a continuously activated tyrosine kinase, which will activate the signals of its downstream pathways, which will cause cell overgrowth and proliferation.

To study the regulation mechanism of ROS1 signal pathway in disease
To study the effect of each virus on ROS1 signaling pathway
To study the effects of drugs or therapies on ROS1 signaling pathways

• Luminex Multiplex Assay
• Enzyme-linked immunosorbent assay (ELISA)
• Flow cytometry (FACS analysis) technology

Detectable targets: p85, SIIP2, GRB1, HAS, GDP, GTP, p110, GAB1, SHP2, MEK, Rac1, TLR4, AKT, RAF, LC3I, PROLC3, ULK, FIP200, mTOR, Ras, UYRAG, NFκB, RIG-1, TRAF3, PDK1, KD, AMBRA1, p38, RIP1, TRAF5, PIP1, SHC, MEK3, p38MAPK, SH2, TRAF6, PIP2, IRS1, MEK6, p50, SLP76, TRAM, PIP3, IRS2, MSK1, p65, Tak1, TRIF, SOS, ISGF3, MSK2