Recombinant Human IL-13 Protein, Seafrom (CAT#: STEM-CT-0081-ZJF)

The Recombinant Human IL-13 Protein manufactured by Seafrom is suitable for studying pro-inflammatory effects and immune responses.
IL-13 is an immune-regulatory cytokine primarily produced by activated Th2 cells, macrophages, and NK cells. Targeted deletion of IL-13 in mice results in impaired Th2 cell development, indicating the critical role of IL-13 in the clearance of gastrointestinal parasites. IL-13 has anti-inflammatory effects on monocytes and macrophages, suppressing the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6, and IL-8. IL-13 has also been shown to promote B cell proliferation and induce isotype switching, thereby increasing IgE production. Blocking IL-13 activity can inhibit the pathological physiological responses in asthma. IL-13 exhibits cross-reactivity in both humans and mice.
The lyophilized form can be stored at 4°C for 24 months. After reconstitution, the liquid can be stored at -20°C for 6-12 months, and it should be avoided to undergo repeated freeze-thaw cycles.

Expression Host: Human HEK293 Cells
Synonyms: NC30 (Human), IL13, ALRH, BHR1, MGC116786, MGC116788, MGC116789, P600, Interleukin-13
Protein Sequence: DNA sequence encodes human IL-13 (GenBank: U31120.1) with a His tag at the C-terminus, contains 118 amino acids, predicted molecular weight of 13.2 kD.
Purity: ≥95%, analyzed by SDS-PAGE and HPLC.
Endotoxin Level: <0.1 EU/μg (gel clot method).
Biological Activity: ED50 determined by dose-dependent proliferation of TF-1 cells is ≤ 1.0 ng/ml, corresponding to specific activity ≥ 1×10^6 U/mg.
Purification Method: Chromatographic purification.

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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